GENETIC PROFILING OF PRIMARY AND SECONDARY TUMORS FROM PATIENTS WITH LUNG ADENOCARCINOMA AND BONE METASTASES REVEALS TARGETED THERAPY OPTIONS

Genetic profiling of primary and secondary tumors from patients with lung adenocarcinoma and bone metastases reveals targeted therapy options

Abstract Background Patients newly diagnosed with lung adenocarcinoma with bone metastases (LABM) have poor survival rates after treatment with conventional therapies.To improve outcomes, we retrospectively investigated whether the application of a more comprehensive genetic test of tumor biopsies samples from LABM patients could provide the basis

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Outcomes of a Physician Survey on the Type, Progression, Assessment, and Treatment of Neurological Disease in Mucopolysaccharidoses

The mucopolysaccharidosis (MPS) disorders are a group of rare, inherited lysosomal storage disorders.In each of the 11 MPS (sub)types, deficiency in a specific lysosomal enzyme (1 of 11 identified enzymes) leads to accumulation of glycosaminoglycans, resulting in cell, tissue, and multi-organ dysfunction.There is great heterogeneity in the clinical

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